SML3188

Isavuconazonium sulfate

≥95% (HPLC)

• Synonim(y): (2-{[(1-{1-[(2R,3R)-3-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-2-(2,5-difluorophenyl)-2-hydroxybutyl]-1H-1,2,4-triazol-4-ium-4-yl}ethoxy)carbonyl](methyl)amino}pyridin-3-yl)methyl N-methylglycinate hydrogen sulfate, BAL 8557-002, BAL8557
• Wzór empiryczny (zapis Hilla): C₃₅H₃₅F₂N₈O₅S · SO₄H
• Numer CAS: 946075-13-4
• Masa cząsteczkowa: 814.84
• UNSPSC Code: 51111800
• NACRES: NA.77
• MDL number: MFCD27987905
• Assay: ≥95% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: O=S(O)([O-])=O.N#CC(C=C1)=CC=C1C2=CSC([C@H](C)[C@](O)(CN3C=[N+](C(C)OC(N(C)C4=NC=CC=C4COC(CNC)=O)=O)C=N3)C5=CC(F)=CC=C5F)=N2
• InChI: 1S/C35H35F2N8O5S.H2O4S/c1-22(33-42-30(18-51-33)25-9-7-24(15-38)8-10-25)35(48,28-14-27(36)11-12-29(28)37)19-45-21-44(20-41-45)23(2)50-34(47)43(4)32-26(6-5-13-40-32)17-49-31(46)16-39-3;1-5(2,3)4/h5-14,18,20-23,39,48H,16-17,19H2,1-4H3;(H2,1,2,3,4)/q+1;/p-1/t22-,23?,35+;/m0./s1
• InChI key: LWXUIUUOMSMZKJ-KLFWAVJMSA-M

Opis

Biochem/physiol Actions

Isavuconazonium sulfate (BAL8557) is a prodrug of isavuconazole (BAL 4815), a triazole antifungal drug. Isavuconazole inhibits fungal sterol biosynthesis by inhibition of cytochrome P450 sterol 14-α-demethylase (CYP51), an enzyme in the sterol biosynthesis pathway that leads from lanosterol to ergosterol. Isavuconazonium sulfate has been approved for the treatment of both invasive aspergillosis and invasive mucormycosis.

Triazole antifungal prodrug.

Ta strona może zawierać tekst przetłumaczony maszynowo.

Informacja o środkach bezpieczeństwa

• Piktogramy: GHS08,GHS07,GHS09
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H302,H361d,H372,H410
• Ostrzeżenia: P202 - P260 - P264 - P273 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - STOT RE 1
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable