1467848

Nobiletin

United States Pharmacopeia (USP) Reference Standard

• Synonim(y): 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one, 3′,4′,5,6,7,8-Hexamethoxyflavone
• Wzór empiryczny (zapis Hilla): C₂₁H₂₂O₈
• Numer CAS: 478-01-3
• Masa cząsteczkowa: 402.39
• NACRES: NA.24
• UNSPSC Code: 41116107
• Beilstein/REAXYS Number: 360887
• MDL number: MFCD03273560

Właściwości

• grade: pharmaceutical primary standard
• agency: USP
• packaging: pkg of 100 mg
• manufacturer/tradename: USP
• application(s): pharmaceutical
• format: neat
• storage temp.: −20°C
• SMILES string: COc1ccc(cc1OC)C2=CC(=O)c3c(OC)c(OC)c(OC)c(OC)c3O2
• InChI: 1S/C21H22O8/c1-23-13-8-7-11(9-15(13)24-2)14-10-12(22)16-17(25-3)19(26-4)21(28-6)20(27-5)18(16)29-14/h7-10H,1-6H3
• InChI key: MRIAQLRQZPPODS-UHFFFAOYSA-N

Opis

General description

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This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets, have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Nobiletin USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Bitter Orange Young Fruit
• Bitter Orange Young Fruit Powder
• Tangerine Peel
• Tangerine Peel Dry Extract
• Tangerine Peel Powder

Biochem/physiol Actions

Nobiletin suppresses the expression of matrix metalloproteinases 1, 3 and 9, which participate in the break down of the extracellular matrix during tumor metastasis. Nobiletin is also involved in the increased expression of tissue inhibitor of matrix metalloproteinase 1 further preventing extracellular matrix degradation during tumor invasion. This bioflavonoid is believed to achieve both of these functions by disrupting the signal transduction pathway of Ras-Raf-MEK.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  

Other Notes

Sales restrictions may apply.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable