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Merck

Monitoring neonatal fungal infection with metabolomics.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (2014-10-07)
Angelica Dessì, Barbara Liori, Pierluigi Caboni, Giovanni Corsello, Mario Giuffrè, Antonio Noto, Francesca Serraino, Mauro Stronati, Marco Zaffanello, Vassilios Fanos
ABSTRAKT

The objective of our study was to evaluate the capability of the metabolomics approach to identify the variations of urine metabolites over time related to the neonatal fungal septic condition. The study population included a clinical case of a preterm neonate with invasive fungal infection and 13 healthy preterm controls. This study showed a unique urine metabolic profile of the patient affected by fungal sepsis compared to urine of controls and it was also possible to evaluate the efficacy of therapy in improving patient health.

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