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Concise total synthesis of (-)-8-epigrosheimin.

Organic letters (2011-06-17)
Haishen Yang, Yuzhe Gao, Xiaoxiao Qiao, Longguan Xie, Xiaohua Xu
PMID21675754
ABSTRACT

A highly efficient route was developed to synthesize (-)-8-epigrosheimin in four steps from aldehyde 2 based on a substrate-controlled method. The key steps of the synthesis included (1) a stereo- and regioselective allylation addition, (2) an intramolecular translactonization, and (3) an aldehyde-ene cyclization.

MATERIALS
Product Number
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Product Description
124931
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