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Merck

07-632

抗-NR2A抗体

Upstate®, from rabbit

别名:

N-methyl D-aspartate receptor subtype 2A, N-methyl-D-aspartate receptor channe, subunit epsilon-1, N-methyl-D-aspartate receptor subunit 2A, NMDA receptor subtype 2A, glutamate receptor, ionotropic, N-methyl D-aspartate 2A

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选择尺寸

200 μG

$863.00

$863.00

预计发货时间2025年12月23日详情

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关于此项目

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

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生物源

rabbit

品質等級

100

共軛

unconjugated

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

polyclonal

物種活性

rat, mouse

製造商／商標名

Upstate®

技術

immunoprecipitation (IP): suitable
western blot: suitable

同型

IgG

NCBI登錄號

NM_008170

UniProt登錄號

Q12879

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

human ... GRIN2A(2903)

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此商品
05-432ABN99AB1555P
抗-NR2A抗体 Upstate®, from rabbit

Sigma-Aldrich

07-632

抗-NR2A抗体

抗-NR1抗体，CT Upstate®, from mouse

Sigma-Aldrich

05-432

抗-NR1抗体，CT

抗磷酸NR1（Ser897）抗体 from rabbit, purified by affinity chromatography

Sigma-Aldrich

ABN99

抗磷酸NR1（Ser897）抗体

抗-NMDAR2A抗体 Chemicon®, from rabbit

Sigma-Aldrich

AB1555P

抗-NMDAR2A抗体

species reactivity

rat, mouse

species reactivity

rat

species reactivity

rat

species reactivity

rat, human, mouse, fish

clone

polyclonal

clone

monoclonal

clone

polyclonal

clone

polyclonal

biological source

rabbit

biological source

mouse

biological source

rabbit

biological source

rabbit

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

affinity purified immunoglobulin

Gene Information

human ... GRIN2A(2903)

Gene Information

human ... GRIN1(2902)
rat ... Grin1(24408)

Gene Information

human ... GRIN1(2902)
mouse ... Grin1(14810)
rat ... Grin1(24408)

Gene Information

human ... GRIN2A(2903)

technique(s)

immunoprecipitation (IP): suitable, western blot: suitable

technique(s)

immunocytochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable

technique(s)

immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable

technique(s)

immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable

一般說明

NR2或谷氨酸受体，离子型，N-甲基D-天冬氨酸2（NMDA2；NMDAR2）与NR1亚基一起形成构成NMDA受体的异二聚体。通过选择性剪接，NR2的各种亚型被分类为NR2A至D。NMDA受体（NMDAR）被表征为谷氨酸的离子型受体。顾名思义，（NMDA（N-甲基D-天冬氨酸）是该受体的激动剂。NMDA受体的一个独特特征是，基于其对镁的灵敏度，它既是配体门控的又是电压依赖性的。NR1亚基结合甘氨酸，而NR2亚基结合谷氨酰胺进行激活。活化的NMDA受体导致打开对阳离子非选择性的离子通道。其结果是Na+和少量Ca2+离子流入细胞，K+流出细胞。NMDARs的钙通量与突触可塑性有关，突触可塑性是细胞学习和记忆的一种机制。
~170 kDa

免疫原

6His标记的融合蛋白，对应于小鼠NMDA受体2A（NR2A）的氨基酸1265-1464。

應用

使用经过验证可用于IP & WB的该抗-NR2A抗体检测NR2A。
免疫沉淀：
从大鼠脑海马膜和大鼠脑微粒体制剂中提取4 µg先前批次免疫沉淀的NR2A。
研究子类别
神经递质 & 受体
研究类别
神经科学

生化／生理作用

识别NR2A，MW ~170 kDa。

外觀

形式：纯化
纯化的兔多克隆IgG，溶于含有70%储存缓冲液（0.1 M Tris-甘氨酸（pH 7.4）、0.15 M NaCl、0.05％叠氮化钠）和30％甘油的缓冲液中。
蛋白A纯化

準備報告

自收到之日起在-20ºC可稳定保存1年。

分析報告

对照
脑组织。
已通过蛋白免疫印迹对大鼠脑微粒体制剂进行了评估（目录号12-144）。

蛋白质印迹分析：
0.5-2 µg/mL该抗体已在大鼠脑微粒体制剂（目录号12-144）中检测到NR2A。

其他說明

浓度：请参考批次特异性浓缩物的分析证书。

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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N-methyl-D-aspartate receptor (NMDAR) ontogeny and subunit expression are altered during developmental lead (Pb²+) exposure. However, it is unknown whether these changes occur at the synaptic or cellular level. Synaptic and extra-synaptic NMDARs have distinct cellular roles, thus, the effects of
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相关内容

Pathways and Biomarkers of Glutamatergic Synapse Flyer

Glutamate is an excitatory neurotransmitter found in the synaptic vesicles of glutamatergic synapses. The post-synaptic neurons in these synapses contain ionotropic and metabotropic glutamate receptors. Glutamate binds to AMPA (α-amino-3-hydroxy-5- methylisoxazole-4-propionic acid) subtype glutamate receptors, leading to sodium influx into the post-synaptic cell and resulting in neuronal excitability and synaptic transmission. The NMDA (N-methyl-d-aspartate) subtype glutamate receptors, on the other hand, regulate synaptic plasticity, and can influence learning and memory. The metabotropic g-protein coupled mGluRs modulate downstream calcium signaling pathways and indirectly influence the synapse’s excitability. The synaptic architecture includes intracellular scaffolding proteins (PSD-95, GRIP), intercellular cell adhesion molecules (NCAMs, N-Cadherins), and a variety of signaling proteins (CaMKII/PKA, PP1/PP2B). Processes critical for synaptic transmission and plasticity are influenced by these molecules and their interactions. When the function of these molecules is disrupted, it leads to synaptic dysfunction and degeneration, and can contribute to dementia as seen in Alzheimer’s disease.

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