H6878

8-羟基喹啉

Name: 8-羟基喹啉
Brand: SIAL
Price: 97 SGD
Availability: InStock

别名:

8-羟基喹啉, 8-氢氧化喹啉, 8-羟基氮杂萘, 喔星

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关于此项目

经验公式（希尔记法）:

C₉H₇NO

化学文摘社编号:

148-24-3

分子量:

145.16

UNSPSC Code:

12352005

NACRES:

NA.21

PubChem Substance ID:

24895771

EC Number:

205-711-1

Beilstein/REAXYS Number:

114512

MDL number:

MFCD00006807

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InChI key

MCJGNVYPOGVAJF-UHFFFAOYSA-N

InChI

1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H

SMILES string

Oc1cccc2cccnc12

assay

≥98.5%

form

powder

mp

72.5-74.0 °C

antibiotic activity spectrum

fungi

mode of action

DNA synthesis | interferes
enzyme | inhibits

Quality Level

200

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此商品	22019	36524	32502
Sigma-Aldrich H6878 8-羟基喹啉	Sigma-Aldrich 22019 8-羟基喹啉	Supelco 36524 8-羟基喹啉	Sigma-Aldrich 32502 8-羟基喹啉
mode of action DNA synthesis \| interferes, enzyme \| inhibits	mode of action DNA synthesis \| interferes, enzyme \| inhibits	mode of action DNA synthesis \| interferes, enzyme \| inhibits	mode of action DNA synthesis \| interferes, enzyme \| inhibits
antibiotic activity spectrum fungi	antibiotic activity spectrum fungi	antibiotic activity spectrum fungi	antibiotic activity spectrum fungi
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 200
form powder	form solid	form -	form solid
assay ≥98.5%	assay ≥99% (perchloric acid titration)	assay 98-100% (GC)	assay ≥99% (perchloric acid titration)
mp 72.5-74.0 °C	mp 70-76 °C, 72.5-74.0 °C	mp 72.5-74.0 °C	mp 72.5-74.0 °C, 72.5-75 °C

Application

用作亲脂性单质双齿螯合剂。

General description

化学结构：喹诺酮

pictograms

GHS06,GHS08,GHS05,GHS09

signalword

Danger

hcodes

H301,H317,H318,H360D,H410

pcodes

P202 - P273 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Repr. 1B - Skin Sens. 1

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000463312

0000463311

0000438824

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Type I Interferon Response Dysregulates Host Iron Homeostasis and Enhances Candida glabrata Infection.

Michael Riedelberger et al.

Cell host & microbe, 27(3), 454-466 (2020-02-23)

Type I interferons (IFNs-I) fulfil multiple protective functions during pathogenic infections, but they can also cause detrimental effects and enhance immunopathology. Here, we report that IFNs-I promote the dysregulation of iron homeostasis in macrophages during systemic infections with the intracellular

Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.

María Isabel Fernández-Bachiller et al.

Journal of medicinal chemistry, 53(13), 4927-4937 (2010-06-16)

Tacrine and PBT2 (an 8-hydroxyquinoline derivative) are well-known drugs that inhibit cholinesterases and decrease beta-amyloid (Abeta) levels by complexation of redox-active metals, respectively. In this work, novel tacrine-8-hydroxyquinoline hybrids have been designed, synthesized, and evaluated as potential multifunctional drugs for

Copper-dependent cytotoxicity of 8-hydroxyquinoline derivatives correlates with their hydrophobicity and does not require caspase activation.

Saverio Tardito et al.

Journal of medicinal chemistry, 55(23), 10448-10459 (2012-11-23)

This study reports the structure-activity relationship of a series of 8-hydroxoquinoline derivatives (8-HQs) and focuses on the cytotoxic activity of 5-Cl-7-I-8-HQ (clioquinol, CQ) copper complex (Cu(CQ)). 8-HQs alone cause a dose-dependent loss of viability of the human tumor HeLa and

Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cells.

Erik H J G Aarntzen et al.

Clinical cancer research : an official journal of the American Association for Cancer Research, 19(6), 1525-1533 (2013-02-06)

Anticancer dendritic cell (DC) vaccines require the DCs to relocate to lymph nodes (LN) to trigger immune responses. However, these migration rates are typically very poor. Improving the targeting of ex vivo generated DCs to LNs might increase vaccine efficacy

An asymmetric synthesis of 1,2,4-trioxane anticancer agents via desymmetrization of peroxyquinols through a Brønsted acid catalysis cascade.

David M Rubush et al.

Journal of the American Chemical Society, 134(33), 13554-13557 (2012-08-09)

The desymmetrization of p-peroxyquinols using a Brønsted acid-catalyzed acetalization/oxa-Michael cascade was achieved in high yields and selectivities for a variety of aliphatic and aryl aldehydes. Mechanistic studies suggest that the reaction proceeds through a dynamic kinetic resolution of the peroxy

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8-羟基喹啉

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