A4847
阿特波龙
≥98% (HPLC), GSK-3β and CDK5/p25 inhibitor, powder
别名:
9-硝基-7,12-二氢吲哚o[3,2-d][1]苯并氮杂卓-6(5H)-酮
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关于此项目
经验公式（希尔记法）:
C16H11N3O3
化学文摘社编号:
分子量:
293.28
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
跳至
产品名称
阿特波龙, ≥98% (HPLC), powder
化驗
≥98% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
yellow to brown
溶解度
DMSO: ≥10 mg/mL
儲存溫度
2-8°C
SMILES 字串
[O-][N+](=O)c1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1
InChI
1S/C16H11N3O3/c20-15-8-12-11-7-9(19(21)22)5-6-14(11)18-16(12)10-3-1-2-4-13(10)17-15/h1-7,18H,8H2,(H,17,20)
InChI 密鑰
OLUKILHGKRVDCT-UHFFFAOYSA-N
基因資訊
rat ... Gsk3b(84027)
相关类别
1 of 4
此商品 | SML0818 | W4016 | S7826 |
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form powder | form powder | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: ≥10 mg/mL | solubility DMSO: 15 mg/mL, clear | solubility DMSO: 10 mg/mL, clear | solubility DMSO: ≥30 mg/mL |
| storage condition desiccated | storage condition - | storage condition - | storage condition - |
應用
Alsterpaullone 已用于稳定 β-catenin。[1]
Alsterpaullone 抑制 GSK-3β、CDK5/p25 和 CDK1/cyclinB。Alsterpaullone 也已被作为抗躁狂药进行研究，用于双相情感障碍急性躁狂期的治疗。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
C Schultz et al.
Journal of medicinal chemistry, 42(15), 2909-2919 (1999-07-30)
The paullones represent a novel class of small molecule cyclin-dependent kinase (CDK) inhibitors. To investigate structure-activity relationships and to develop paullones with antitumor activity, derivatives of the lead structure kenpaullone (9-bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one, 4a) were synthesized. Paullones with different substituents in the
Michael Trevino et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 240(12), 2673-2679 (2011-11-05)
Although regeneration is widespread among metazoa, the molecular mechanisms have been studied in only a handful of taxa. Of these taxa, fewer still are amenable to studies of embryogenesis. Our understanding of the evolution of regeneration, and its relation to
Mikhail Kalinichev et al.
The international journal of neuropsychopharmacology, 14(8), 1051-1067 (2011-01-07)
There is a growing body of evidence suggesting that animal models can be developed to probe the specific domains of bipolar disorder (BD) using the endophenotype approach. Here we tested clinically active antimanic drugs to validate amphetamine-induced hyperactivity in Black
Laura Iglesias Ollé et al.
Biomedicines, 12(6) (2024-06-27)
Hydra head formation depends on an organizing center in which Wnt/β-catenin signaling, that plays an inductive role, positively regulates Sp5 and Zic4, with Sp5 limiting Wnt3/β-catenin expression and Zic4 triggering tentacle formation. Using transgenic lines in which the HySp5 promoter
Tsuneo Takadera et al.
Neurotoxicity research, 21(3), 309-316 (2011-10-19)
In the central nervous system, members of the Src family of tyrosine kinases (SFKs) are widely expressed and are abundant in neurons. The purpose of this study is to examine whether glycogen synthase-3 (GSK-3) is involved in SFK inhibitor-induced apoptosis.
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