A8351

氨苄西林 钠盐

BioXtra, suitable for cell culture

• 别名: 氨苄青霉素 钠盐
• 经验公式（希尔记法）: C₁₆H₁₈N₃NaO₄S
• 化学文摘社编号: 69-52-3
• 分子量: 371.39
• Beilstein: 4119211
• EC號碼: 200-708-1
• MDL號碼: MFCD00064313
• 分類程式碼代碼: 51281716
• PubChem物質ID: 24891335
• NACRES: NA.76

属性

• 產品線: BioXtra
• 形狀: powder
• 技術: cell culture | mammalian: suitable
• 雜質: endotoxin, tested
• 顏色: white to off-white
• mp: 215 °C (dec.) (lit.)
• 抗生素活性譜: Gram-negative bacteria; Gram-positive bacteria
• 作用方式: cell wall synthesis | interferes
• 儲存溫度: 2-8°C
• SMILES 字串: [Na+].CC1(C)SC2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C([O-])=O
• InChI: 1S/C16H19N3O4S.Na/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8;/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23);/q;+1/p-1/t9-,10-,11+,14-;/m1./s1
• InChI 密鑰: KLOHDWPABZXLGI-YWUHCJSESA-M

说明

一般說明

Chemical structure: ß-lactam

應用

Ampicillin is a semi-synthetic derivative of penicillin that functions as a broad-spectrum antibiotic. It has been used to study antibiotic resistance and penetration limitations, the synergy between multiple antibiotics, certain bloodstream infections, and has been used to develop PCR assays to detect resistance genes in cerebrospinal fluid.

生化／生理作用

作用方式：该ß-内酰胺抗生素通过灭活位于细菌的细胞膜内表面的转肽酶从而抑制细菌细胞壁合成。

耐药性机制：ß-内酰胺酶切开氨苄青霉素的ß-内酰胺环,使其失去活性。

抗菌谱：包括革兰氏阳性菌(类似青霉素)和革兰氏阴性菌(类似四环素和氯霉素)。

準備報告

Ampicillin is reported as slightly soluble in water, practically insoluble in alcohol, chloroform, ether and fixed oils but soluble in dilute acids or bases. The solution should not be autoclaved; a stock solution should be sterilized through filtration and stored frozen, where it will be stable for months.

其他說明

Keep container tightly closed in a dry and well-ventilated place, hygroscopic.

免責聲明

This product has been reported stable as supplied at 25°C at 43% and 81% relative humidity for six weeks. Additional studies have shown that the stability of Ampicillin in solution is a function of pH, temperature and the identity of the buffer. It′s activity is quickly lost when stored above pH 7. Optimal storage conditions are suggested as 2-8°C, and pH 3.8-5 where its activity was retained at 90%+ for a week.

安全信息

• 象形圖: GHS08
• 訊號詞: Danger
• 危險聲明: H317,H334
• 防範說明: P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
• 危險分類: Resp. Sens. 1A - Skin Sens. 1A
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Faceshields, Gloves