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Merck

S4526

盐霉素

from Streptomyces albus, ≥98% (HPLC), powder, MDRP-1 inhibitor

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关于此项目

经验公式（希尔记法）:
C42H70O11
化学文摘社编号:
53003-10-4
分子量:
751.00
EC號碼:
258-290-1
分類程式碼代碼:
12352200
PubChem物質ID:
329824546
NACRES:
NA.77

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产品名称

盐霉素, from Streptomyces albus, ≥98% (HPLC)

生物源

Streptomyces albus

品質等級

200

化驗

≥98% (HPLC)

mp

112.5-113.5 °C (lit.)

抗生素活性譜

neoplastics

作用方式

cell membrane | interferes

儲存溫度

2-8°C

SMILES 字串

CC[C@H]([C@H]1CC[C@H](C)[C@@H](O1)[C@@H](C)[C@H](O)[C@H](C)C(=O)[C@H](CC)[C@H]2O[C@@]3(O[C@@]4(CC[C@](C)(O4)[C@H]5CC[C@](O)(CC)[C@H](C)O5)[C@H](O)C=C3)[C@H](C)C[C@@H]2C)C(O)=O

InChI

1S/C42H70O11/c1-11-29(38(46)47)31-15-14-23(4)36(50-31)27(8)34(44)26(7)35(45)30(12-2)37-24(5)22-25(6)41(51-37)19-16-32(43)42(53-41)21-20-39(10,52-42)33-17-18-40(48,13-3)28(9)49-33/h16,19,23-34,36-37,43-44,48H,11-15,17-18,20-22H2,1-10H3,(H,46,47)/t23-,24-,25+,26-,27-,28-,29+,30-,31+,32+,33+,34+,36+,37-,39-,40+,41-,42-/m0/s1

InChI 密鑰

KQXDHUJYNAXLNZ-XQSDOZFQSA-N

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此商品
V363994675V0627
盐霉素 from Streptomyces albus, ≥98% (HPLC)

Sigma-Aldrich

S4526

盐霉素

缬氨霉素 Ready Made Solution, ~1 mg/mL in DMSO

Sigma-Aldrich

V3639

缬氨霉素

缬氨霉素 ≥99.0% (TLC)

Sigma-Aldrich

94675

缬氨霉素

缬氨霉素 ≥98% (TLC), ≥90% (HPLC)

Sigma-Aldrich

V0627

缬氨霉素

assay

≥98% (HPLC)

assay

≥90% (HPLC)

assay

≥99.0% (TLC)

assay

≥90% (HPLC), ≥98% (TLC)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

300

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

biological source

Streptomyces albus

biological source

Streptomyces sp.

biological source

-

biological source

-

mp

112.5-113.5 °C (lit.)

mp

-

mp

187-190 °C

mp

-

antibiotic activity spectrum

neoplastics

antibiotic activity spectrum

Gram-positive bacteria, parasites, viruses

antibiotic activity spectrum

mycobacteria

antibiotic activity spectrum

Gram-positive bacteria, parasites, viruses

一般說明

Chemical structure: polyether

應用

Salinomycin was used as a standard in the development of LC-MS/MS method for detection of residual coccidiostats in egg and muscle samples.[1] It was used to screen out CD44+CD24- mesenchymal-like subpopulation within breast carcinomas.[2]

生化／生理作用

Salinomycin produced by Streptomyces albus is a carboxylic polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma. Salinomycin inhibits multidrug resistance protein 1 and induces apoptosis by the generation of reactive oxygen species that cause DNA damage and inactivation of Stat3.[3][4] Use of salinomycin as antibiotic results in lowered spermatozoa count and motility and decreased steroidogenesis in mice.[5]

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險聲明

H300

危險分類

Acute Tox. 2 Oral

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000462909
0000462909
0000141658
0000202393
0000419120

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Jan Czerwiński et al.
Archives of animal nutrition, 66(2), 102-116 (2012-05-31)
The effect of dietary sodium butyrate (SB) or salinomycin (SAL) or both additives on performance, small intestinal morphology and microbial ecology of broiler chickens was studied. A growth trial was conducted with 96 Ross 308 female broilers from 1 to
J S van der Linde-Sipman et al.
Veterinary pathology, 36(2), 152-156 (1999-03-31)
In April 1996, an outbreak of toxic polyneuropathy in cats occurred in the Netherlands. All cats had been fed one of two brands of dry cat food from one manufacturer. Chemical analyses of these foods, stomach contents, and liver and
Soshi Kusunoki et al.
Gynecologic oncology, 129(3), 598-605 (2013-03-19)
We previously demonstrated that side-population (SP) cells in human endometrial cancer cells (Hec1 cells) and in rat endometrial cells expressing oncogenic human K-Ras protein (RK12V cells) have features of cancer stem cells (CSCs). Hec1-SP cells showed enhanced migration and the
Devraj Basu et al.
Cell cycle (Georgetown, Tex.), 10(12), 2008-2016 (2011-05-12)
Curative eradication of all cells within carcinomas is seldom achievable with chemotherapy alone. This limitation may be partially attributable to tumor cell subpopulations with intrinsic resistance to current drugs. Within squamous cell carcinoma (SCC) cell lines, we previously characterized a
Bei Zhang et al.
Oncology reports, 29(4), 1371-1378 (2013-01-23)
In order to search for alternative agents to overcome chemoresistance during the treatment of ovarian cancer, this study aimed to examine the anticancer effects and action mechanism of salinomycin, a selective inhibitor of cancer stem cells, on cisplatin-resistant human ovarian
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