SML1274
RI-1
≥98% (HPLC)
别名:
3-Chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione
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选择尺寸
5 MG
$133.00
25 MG
$525.00
$133.00
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关于此项目
经验公式（希尔记法）:
C14H11Cl3N2O3
化学文摘社编号:
分子量:
361.61
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
跳至
产品名称
RI-1, ≥98% (HPLC)
InChI
1S/C14H11Cl3N2O3/c15-9-2-1-8(7-10(9)16)19-13(20)11(17)12(14(19)21)18-3-5-22-6-4-18/h1-2,7H,3-6H2
SMILES string
ClC1=C(Cl)C=CC(N2C(C(N3CCOCC3)=C(Cl)C2=O)=O)=C1
InChI key
MWSUIZKGNWELRF-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
yellow to orange
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
Quality Level
1 of 4
此商品 | SML2240 | SML0800 | SML0599 |
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form powder | form powder | form powder | form powder |
| Quality Level 100 | Quality Level - | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 10 mg/mL, clear | solubility DMSO: 2 mg/mL, clear | solubility DMSO: 20 mg/mL, clear | solubility DMSO: 20 mg/mL, clear |
| color yellow to orange | color white to beige | color white to beige | color white to beige |
Biochem/physiol Actions
RI-1 is a cell-permeable RAD51 inhibitor that binds covalently to the protein surface at Cysteine 319. RI-1 disrupts homologous recombination in human cells.
RI-1 is a cell-permeable RAD51 inhibitor.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Todd W Lewis et al.
Nucleic acids research, 47(7), 3503-3520 (2019-02-05)
The primary function of the UBE2T ubiquitin conjugase is in the monoubiquitination of the FANCI-FANCD2 heterodimer, a central step in the Fanconi anemia (FA) pathway. Genetic inactivation of UBE2T is responsible for the phenotypes of FANCT patients; however, a FANCT
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