H2O: soluble 100 mg/mL, clear to slightly hazy, colorless to yellow
solubility
-
solubility
H2O: soluble ~33 mg/mL
solubility
-
originator
Novartis
originator
Sanofi Aventis
originator
AstraZeneca
originator
-
Gene Information
human ... ADRB1(153), ADRB2(154), ADRB3(155)
Gene Information
human ... ADRB1(153), ADRB2(154), ADRB3(155)
Gene Information
-
Gene Information
human ... ADRB2(154)
應用
Terbutaline hemisulfate has been used as a reference standard for the determination of β agonist residues in meat4. It has also been used as a standard for developing LC-MS-MS based techniques for the analysis of veterinary drugs5.
生化／生理作用
Terbutaline is a β-adrenoceptor agonist and is known to function as a bronchodilator. Studies have reported that terbutaline is potent inhibitor of premature labor6.
特點和優勢
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準備報告
Terbutaline hemisulfate salt dissolves in water at 100 mg/ml to yield a colorless to yellow, clear to slightly hazy solution.
International journal of sports medicine, 33(12), 1026-1033 (2012-07-12)
We examined urine and serum concentrations after therapeutic use of single and repetitive doses of inhaled and supratherapeutic oral use of terbutaline. We compared the concentrations in 10 asthmatics and 10 healthy subjects in an open-label, cross-over study with 2
The Cochrane database of systematic reviews, 12, CD010179-CD010179 (2012-12-14)
Inhaled beta-agonist therapy is central to the management of acute asthma. This review evaluates the benefit of an additional use of intravenous beta(2)-agonist agents. To determine the benefit of adding intravenous (IV) beta(2)-agonists to inhaled beta(2)-agonist therapy for acute asthma
Journal of veterinary pharmacology and therapeutics, 21(5), 388-392 (1998-11-12)
Beta2-adrenoceptor agonists are used as bronchodilators in both humans and horses. Of these drugs, clenbuterol is the one most frequently used when treating chronic obstructive pulmonary disease in the horse, while salbutamol and terbutaline are used in the treatment of
Neurotoxicology and teratology, 36, 91-96 (2012-07-21)
Terbutaline, a β2-adrenoceptor agonist, is used off-label for long-term management of preterm labor; such use is associated with increased risk of neurodevelopmental disorders, including autism spectrum disorders. We explored the mechanisms underlying terbutaline's effects on development of peripheral sympathetic projections
American journal of obstetrics and gynecology, 125(4), 520-524 (1976-06-15)
The effect of terbutaline, a "selective" beta2-receptor stimulator, was compared with that of placebo in 30 patients in premature labor. Treatment consisted of an intravenous infusion for at least 8 hours, and then of subcutaneous injections four times daily for
