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Merck

50940

Guanidine hydrochloride

≥99.0% (AT)

Synonym(s):

Aminoformamidine hydrochloride, Aminomethanamidine hydrochloride, Guanidinium chloride

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About This Item

Linear Formula:
NH2C(=NH)NH2 · HCl
CAS Number:
50-01-1
Molecular Weight:
95.53
UNSPSC Code:
12352107
NACRES:
NA.55
PubChem Substance ID:
329757653
EC Number:
200-002-3
Beilstein/REAXYS Number:
3591990
MDL number:
MFCD00013026

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Product Name

Guanidine hydrochloride, ≥99.0% (AT)

InChI key

PJJJBBJSCAKJQF-UHFFFAOYSA-N

InChI

1S/CH5N3.ClH/c2-1(3)4;/h(H5,2,3,4);1H

SMILES string

Cl[H].NC(N)=N

assay

≥99.0% (AT)

form

solid

ign. residue

≤0.1% (as SO4)

pH

(25 °C, 4.6 - 6/573 g/L)

mp

180-185 °C (lit.)

solubility

H2O: 6 M at 20 °C, clear, colorless

density

1.3 g/cm3 (lit.)

anion traces

sulfate (SO42-): ≤50 mg/kg

cation traces

Ca: ≤20 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

Quality Level

200

Gene Information

human ... KCNA1(3736), KCNA10(3744), KCNA2(3737), KCNA3(3738), KCNA4(3739), KCNA5(3741), KCNA6(3742), KCNA7(3743), KCNB1(3745), KCNB2(9312), KCNC1(3746), KCNC2(3747), KCNC3(3748), KCNC4(3749), KCND1(3750), KCND2(3751), KCND3(3752), KCNF1(3754), KCNG1(3755), KCNG2(26251), KCNG3(170850), KCNG4(93107), KCNH1(3756), KCNH2(3757), KCNH3(23416), KCNH4(23415), KCNH5(27133), KCNH6(81033), KCNH7(90134), KCNH8(131096), KCNQ1(3784), KCNQ2(3785), KCNQ3(3786), KCNQ4(9132), KCNQ5(56479), KCNS1(3787), KCNS2(3788), KCNS3(3790), KCNV1(27012), KCNV2(169522)

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Show Differences

1 of 4

This Item
5095050933G4505
Guanidine hydrochloride ≥99.0% (AT)

Sigma-Aldrich

50940

Guanidine hydrochloride

Guanidine hydrochloride ≥98%

Sigma-Aldrich

50950

Guanidine hydrochloride

Guanidine hydrochloride BioUltra, Molecular Biology, ≥99.5% (AT)

Sigma-Aldrich

50933

Guanidine hydrochloride

Guanidine hydrochloride organic base and chaeotropic agent, ≥99% (titration)

Sigma-Aldrich

G4505

Guanidine hydrochloride

assay

≥99.0% (AT)

assay

≥98%

assay

≥99.5% (AT)

assay

≥99% (titration)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

400

form

solid

form

powder or crystals

form

powder or crystals

form

crystalline powder

density

1.3 g/cm3 (lit.)

density

1.3 g/cm3 (lit.)

density

1.3 g/cm3 (lit.)

density

1.3 g/cm3 (lit.)

solubility

H2O: 6 M at 20 °C, clear, colorless

solubility

H2O: 6 M, clear (100 Hazen)

solubility

H2O: 6 M at 20 °C, clear, colorless

solubility

H2O: 6 M

pH

(25 °C, 4.6 - 6/573 g/L)

pH

(25 °C, 4.6 - 6/573 g/L)

pH

4.5-6.0 (25 °C, 6 M in H2O)

pH

(25 °C, 4.6 - 6 at 573 g/L)

Application

Strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF7019V
WXBF6155V
WXBF3022V
WXBF2692V
WXBD8477V

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Manula S B Rathnayake et al.
Cartilage, 13(2_suppl), 476S-485S (2021-03-23)
To investigate GAG-ECM (glycosaminoglycan-extracellular matrix) interactions in different cartilage types. To achieve this, we first aimed to determine protocols for consistent calculation of GAG content between cartilage types. Auricular cartilage containing both collagen and elastin was used to determine the
D T Gruszka et al.
Science advances, 6(38) (2020-09-20)
During replication, nucleosomes are disrupted ahead of the replication fork, followed by their reassembly on daughter strands from the pool of recycled parental and new histones. However, because no previous studies have managed to capture the moment that replication forks
Caitriona McKeever et al.
Journal of medicinal chemistry, 56(3), 700-711 (2013-01-11)
Considering the strong DNA minor groove binding observed for our previous series of diaromatic symmetric and asymmetric guanidinium and 2-aminoimidazolinium derivatives, we report now the synthesis of new aminoalkyl derivatives of diaromatic guanidines with potential as DNA minor groove binders
Masaatsu Adachi et al.
The Journal of organic chemistry, 78(4), 1699-1705 (2013-01-18)
We describe an improved synthesis of (-)-5,11-dideoxytetrodotoxin from an enone, which was used for synthesis of tetrodotoxin and its analogues in this laboratory. One of the major modifications was to establish a two-step guanidinylation of trichloroacetamide of a highly functionalized
Fackson Mwale et al.
Tissue engineering. Part A, 20(21-22), 2942-2949 (2014-05-03)
Link N is a naturally occurring peptide that can stimulate proteoglycan synthesis in intervertebral disc (IVD) cells. IVD repair can also potentially be enhanced by mesenchymal stem cell (MSC) supplementation to maximize extracellular matrix (ECM) production. In a previous study
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