MilliporeSigma

EGFR

epidermal growth factor receptor

Synonyms:
ERBB, ERBB1, HER1, PIG61, mENA
Species:
UniProtKB ID:
Gene ID:
  • Human(1956) Summary: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
  • Mouse(13649) epidermal growth factor receptor
  • Rat(24329) epidermal growth factor receptor
  • sheep(780479) epidermal growth factor receptor
  • domestic guinea pig(100725363) epidermal growth factor receptor
  • dog(404306) epidermal growth factor receptor
  • fruit fly(37455) Epidermal growth factor receptor
  • Horse(100067755) epidermal growth factor receptor
  • cow(407217) epidermal growth factor receptor
  • naked mole-rat(101723771) epidermal growth factor receptor
  • domestic cat(100510799) epidermal growth factor receptor
  • chicken(396494) epidermal growth factor receptor

Custom & Knockdown Gene Products

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ELISA

Product Number
Description
Species
Cell-Based ELISA for detecting phospho-EGFR, in cultured cell lines, 96 assays,
Species
human
Phosphotyrosine EGFR / Epidermal Growth Factor Receptor ELISA Kit, ,
Species
human
Phospho-EGFR (pTyr1068) ELISA Kit, for detection of human phospho-egfr (pTyr1068) in cell and tissue lysates,
Species
human
Phospho-EGFR (pTyr992) and pan-EGFR ELISA Kit, for detection of human phospho-egfr (pTyr992) and pan-egfr in cell and tissue lysates,
Species
human
Human EGFR / ErbB1 ELISA Kit, for serum, plasma, cell culture supernatants and urine,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
Tyrphostin AG 1478, ≥98%,
Species
human, mouse
SU 5416, ≥98% (HPLC),
Species
human, mouse
Genistein, synthetic, ≥98% (HPLC), powder,
Species
mouse, human, rat
Genistein, from Glycine max (soybean), ~98% (HPLC),
Species
mouse, human, rat

Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-Epidermal Growth Factor Receptor antibody produced in mouse, clone F4, ascites fluid,
Species Reactivity
human
Application
ELISA
immunohistochemistry

immunoprecipitation (IP)

microarray

western blot
Anti-phospho-Epidermal Growth Factor Receptor (pTyr1068) antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, rat
Application
western blot
Anti-EGF Receptor antibody, Mouse monoclonal, clone 225, purified from hybridoma cell culture,
Species Reactivity
human
Application
immunoprecipitation (IP)
Monoclonal Anti-EGFR antibody produced in mouse, clone 4H2, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
Anti-phospho-EGFR (pTyr1197) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
DAPH, ≥98% (HPLC), solid,
Species
human
Gefitinib for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human
Erlotinib hydrochloride, ,
Species
human
PKI-166, ≥98% (HPLC),
Species
human
Gefitinib, ≥98% (HPLC),
Species
human

Proteins

Product Number
Description
Species
Epidermal Growth Factor Receptor human, buffered aqueous glycerol solution, 5,000-30,000 units/mg protein (Lowry),
Species
human
Epidermal Growth Factor Receptor human, lyophilized powder, ≥15,000 units/mg protein (Bradford),
Species
human
EGF-receptor human, recombinant, expressed in CHO cells, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture,
Species
human
EGFR Active human, recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE),
Species
human
EGFR (C797S), Active, recombinant,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Egfr,
Species
mouse
MISSION® esiRNA, targeting human EGFR,
Species
human