MilliporeSigma

PPARD

peroxisome proliferator-activated receptor delta

Synonyms:
FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB
Species:
UniProtKB ID:
Gene ID:
  • Human(5467) Summary: This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]
  • Mouse(19015) peroxisome proliferator activator receptor delta
  • Rat(25682) peroxisome proliferator-activated receptor delta
  • naked mole-rat(101722175) peroxisome proliferator-activated receptor delta
  • domestic guinea pig(100725136) peroxisome proliferator-activated receptor delta
  • chicken(395479) peroxisome proliferator-activated receptor delta
  • dog(481756) peroxisome proliferator-activated receptor delta
  • domestic cat(101098383) peroxisome proliferator-activated receptor delta
  • Horse(100053404) peroxisome proliferator-activated receptor delta
  • cow(353106) peroxisome proliferator-activated receptor delta
  • sheep(101117625) peroxisome proliferator-activated receptor delta

Custom & Knockdown Gene Products

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Small Molecule - Activator

Product Number
Description
Species
WY-14643, ,
Species
rat, human, mouse
Bezafibrate, ≥98%, solid,
Species
mouse, human

Small Molecule - Agonist

Product Number
Description
Species
2-Bromohexadecanoic acid, ~97%,
Species
human
L-165,041, ≥98% (HPLC), powder,
Species
human
2-Bromohexadecanoic acid, ≥99.0% (GC),
Species
human
Bezafibrate, European Pharmacopoeia (EP) Reference Standard,
Species
human
Bezafibrate, British Pharmacopoeia (BP) Reference Standard,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
GW0742, ≥98% (HPLC),
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-PPARD antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
western blot
Monoclonal Anti-PPARD antibody produced in mouse, clone 1G4, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
Anti-PPAR δ (Isoform 1) antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
Anti-Peroxisome Proliferator Activated Receptor δ antibody produced in rabbit, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
mouse
Application
western blot

Proteins

Product Number
Description
Species
PPARβ, ligand binding domain (165-441) human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE),
Species
human
PPAR δ, ligand binding domain (165-441), GST tagged human, recombinant, expressed in E. coli, ≥80% (SDS-PAGE),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human PPARD,
Species
human
MISSION® esiRNA, targeting mouse Ppard,
Species
mouse