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SRP2139

Sigma-Aldrich

PPAR δ, ligand binding domain (165-441), GST tagged human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

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Synonym(s):
FAAR, MGC3931, NR1C2, NUC1, NUCI, NUCII, PPARB
NACRES:
NA.26

biological source

human

recombinant

expressed in E. coli

assay

≥80% (SDS-PAGE)

form

frozen liquid

mol wt

~58.2 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

concentration

300 μg/mL

color

clear colorless

NCBI accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... PPARD(5467)

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This Item
SRP2135SRP2140SRP2045
PPAR, γ human recombinant, expressed in E. coli, ≥70% (SDS-PAGE)

SRP2045

PPAR, γ human

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

assay

≥80% (SDS-PAGE)

assay

≥80% (SDS-PAGE)

assay

≥80% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

concentration

300 μg/mL

concentration

-

concentration

450 μg/mL

concentration

500 μg/mL

mol wt

~58.2 kDa

mol wt

~60.2 kDa

mol wt

~57.8 kDa

mol wt

~60 kDa

form

frozen liquid

form

frozen liquid

form

frozen liquid

form

frozen liquid

Biochem/physiol Actions

There is evidence that a group of closely related nuclear receptors, called peroxisome proliferator-activated receptors (PPARs), may be involved in chronic diseases such as diabetes, obesity, artherosclerosis and cancer. The PPARs were first cloned as the nuclear receptors that mediate the effects of synthetic compounds called peroxisome proliferators on gene transcription. It soon became clear that eicosanoids and fatty acids can also regulate gene transcription through PPARs. They bind a specific element in the promoter region of target genes only as a heterodimer with the receptor for 9- cis retinoic acid, RXR (retinoid X receptor). Binding of the ligand of either receptor can activate the complex, but binding of both ligands simultaneously is more potent. Three PPAR isotypes have been identified: α, β (also called NUC1) and γ. PPARβ is found in many tissues but the highest expression is in the gut, kidney and heart. PPARβ or PPARδ have received little attention, probably because of the lack of a connection with important clinical manifestations. However, recently PPARβ has been linked to colon cancer (3) and as an inducer of COX-2 expression in carcinogenesis, among other functions. PPAR regulates the expression of acyl-CoA synthetase 2 in the brain, linking PPARβ to basic lipid metabolism. Moreover, it probably participates in embryo implantation and decidualization.

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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T C He et al.
Cell, 99(3), 335-345 (1999-11-11)
PPARB was identified as a target of APC through the analysis of global gene expression profiles in human colorectal cancer (CRC) cells. PPARdelta expression was elevated in CRCs and repressed by APC in CRC cells. This repression was mediated by
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
B Desvergne et al.
Endocrine reviews, 20(5), 649-688 (1999-10-26)
S Kersten et al.
Nature, 405(6785), 421-424 (2000-06-06)
In developed societies, chronic diseases such as diabetes, obesity, atherosclerosis and cancer are responsible for most deaths. These ailments have complex causes involving genetic, environmental and nutritional factors. There is evidence that a group of closely related nuclear receptors, called

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