Nanofibrillar Patches of Commensal Skin Bacteria.

Biomacromolecules (2018-07-07)
Karine Glinel, Adam Behrens, Robert S Langer, Ana Jaklenec, Alain M Jonas

We demonstrate entrapment of the commensal skin bacteria Staphylococcus epidermidis in mats composed of soft nanotubes made by membrane-templated layer-by-layer (LbL) assembly. When cultured in broth, the resulting nanofibrillar patches efficiently delay the escape of bacteria and their planktonic growth, while displaying high steady-state metabolic activity. Additionally, the material properties and metabolic activity can be further tuned by postprocessing the patches with additional polysaccharide LbL layers. These patches offer a promising methodology for the fabrication of bacterial skin dressings for the treatment of skin dysbiosis while preventing adverse effects due to bacterial proliferation.

Product Number
Product Description

Calcium chloride, anhydrous, granular, ≤7.0 mm, ≥93.0%
Sodium alginate