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  • Ribophorin II is upregulated in myelodysplastic syndromes and prevents apoptosis and cell cycle progression.

Ribophorin II is upregulated in myelodysplastic syndromes and prevents apoptosis and cell cycle progression.

Experimental biology and medicine (Maywood, N.J.) (2020-05-26)
Jinhai Ren, Ying Wang, Lihua Wang, Xiaoling Guo, Xiaonan Guo
ABSTRACT

This study explored the role of ribophorin II (RPN2) in myelodysplastic syndromes (MDSs) cell proliferation and growth and revealed that RPN2 knockdown suppressed OCI-AML3 cell growth and proliferation and triggered cell cycle arrest and elicited apoptosis in OCI-AML3 cells. In addition, it shed light on the etiology of RPN2's role in MDS cell proliferation that RPN2 can negatively impact enhancer of zeste homolog-2 (EZH2) expression, which in turn is able to modulate the cell cycle location and death in OCI-AML3 cells. Hence, RPN2 expression could be a latent predictor of prognosis in patients with MDS.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
MISSION® esiRNA, targeting human RPN2
Sigma-Aldrich
MISSION® esiRNA, targeting human CHN1