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Similarity of synthetic peptide from human tumor to parathyroid hormone in vivo and in vitro.

Science (New York, N.Y.) (1987-12-11)
N Horiuchi, M P Caulfield, J E Fisher, M E Goldman, R L McKee, J E Reagan, J J Levy, R F Nutt, S B Rodan, T L Schofield
ABSTRACT

One mechanism considered responsible for the hypercalcemia that frequently accompanies malignancy is secretion by the tumor of a circulating factor that alters calcium metabolism. The structure of a tumor-secreted peptide was recently determined and found to be partially homologous to parathyroid hormone (PTH). The amino-terminal 1-34 region of the factor was synthesized and evaluated biologically. In vivo it produced hypercalcemia, acted on bone and kidney, and stimulated 1,25-dihydroxy-vitamin D3 formation. In vitro it interacted with PTH receptors and, in some systems, was more potent than PTH. These studies support a long-standing hypothesis regarding pathogenesis of malignancy-associated hypercalcemia.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Hypercalcemia of malignancy factor fragment 1-34 amide human, ≥97% (HPLC)

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