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Opto-Thermal Transient Emission Radiometry (OTTER) to image diffusion in nails in vivo.

International journal of pharmaceutics (2011-01-22)
P Xiao, X Zheng, R E Imhof, K Hirata, W J McAuley, R Mateus, J Hadgraft, M E Lane
ABSTRACT

This work describes the first application of Opto-Thermal Transient Emission Radiometry (OTTER), an infrared remote sensing technique, to probe the extent to which solvents permeate the human nail in vivo. Decanol, glycerol and butyl acetate were selected as model solvents. After application of the solvents, individually, to human volunteers, OTTER was used to depth profile the solvents. The permeation rate of the solvents was ranked as glycerol>decanol>butyl acetate. It is possible that some of the butyl acetate may have evaporated during the experiment. The ability of decanol to extract lipids from biological tissue is also considered. These preliminary results demonstrate the potential of OTTER as a tool to identify optimal excipients with which to target drugs to the nail.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Butyl acetate, anhydrous, ≥99%
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Butyl acetate, ACS reagent, ≥99.5%
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Butyl acetate, suitable for HPLC, 99.7%
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Butyl acetate, natural, ≥98%, FG
Supelco
Butyl acetate, analytical standard
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Butyl acetate, ≥99%, FCC, FG
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Butyl acetate, ReagentPlus®, 99.5%
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Butyl acetate, Pharmaceutical Secondary Standard; Certified Reference Material
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Butyl acetate, puriss. p.a., ACS reagent