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Synthesis of β-ionone derived chalcones as potent antimicrobial agents.

Bioorganic & medicinal chemistry letters (2012-09-25)
Vishal Sharma, Gurpreet Singh, Harpreet Kaur, Ajit K Saxena, Mohan Paul S Ishar
ABSTRACT

A series of chalcones (3a-v) have been synthesized by condensation of β-ionone (1) with a variety of aldehydes (2a-v). The synthesized compounds have been screened for their in vitro antimicrobial activity against five bacterial and five fungal strains, using disc diffusion assay. The evaluated compounds display a wide range of activities, from completely inactive to the highly active compounds. Some of the compounds are also active against methicillin resistant staphylococcus aureus (MRSA).

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
β-Ionone, 96%
Sigma-Aldrich
β-Ionone, predominantly trans, ≥97%, FCC, FG
Sigma-Aldrich
β-Ionone, natural, ≥95%, FG