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Oligomers with pendant isocyanate groups as tissue adhesives. I. Synthesis and characterization.

Journal of biomedical materials research (1989-03-01)
G M Brauer, C H Lee

A series of methacrylate oligomers containing pendant isocyanate groups were synthesized by reacting 2-isocyanatoethyl methacrylate (IEM) and/or m-isopropenyl-alpha, alpha-dimethylbenzyl isocyanate (TMI) in ethoxyethyl acetate with methacrylates ranging from methyl to stearyl methacrylate or allyl-, cyclohexyl-, glycidyl-, i-bornyl-, or dicyclopentenyloxyethyl methacrylate. The oligomers which are stable at room temperature were characterized by IR for NCO, ester, and C = C groups and by their refractive indices. They have a small number of residual double bonds and a molecular weight low enough so that the compounds are liquids at room temperature and dissolve readily in esters and chlorinated hydrocarbons. HPLC showed no residual monomer. GPC and intrinsic viscosity of selected oligomers indicated a molecular weight range from 1400 to 2600. Isocyanate groups were determined titrimetrically and ranged from 15.9% to 5.1%. Concurrent studies have demonstrated that these oligomers bond strongly to hard and soft tissues. Thus, subject to their biocompatibility they could find many applications as tissue adhesives.

Product Number
Product Description

2-Isocyanatoethyl methacrylate, contains ≤0.1% BHT as inhibitor, 98%
3-Isopropenyl-α,α-dimethylbenzyl isocyanate, 95%, contains ≤200 ppm BHT as inhibitor

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