• Home
  • Search Results
  • Cellular and intracellular mechanisms involved in the cognitive impairment of cannabinoids.

Cellular and intracellular mechanisms involved in the cognitive impairment of cannabinoids.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences (2012-10-31)
Emma Puighermanal, Arnau Busquets-Garcia, Rafael Maldonado, Andrés Ozaita
ABSTRACT

Exogenous cannabinoids, such as delta9-tetrahydrocannabinol (THC), as well as the modulation of endogenous cannabinoids, affect cognitive function through the activation of cannabinoid receptors. Indeed, these compounds modulate a number of signalling pathways critically implicated in the deleterious effect of cannabinoids on learning and memory. Thus, the involvement of the mammalian target of rapamycin pathway and extracellular signal-regulated kinases, together with their consequent regulation of cellular processes such as protein translation, play a critical role in the amnesic-like effects of cannabinoids. In this study, we summarize the cellular and molecular mechanisms reported in the modulation of cognitive function by the endocannabinoid system.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Arachidonylethanolamide, ≥97.0% (TLC), oil