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Parallel solution phase synthesis of 3,6,7-4(3H)-quinazolinones and evaluation of their antitumor activities against human cancer.

Journal of combinatorial chemistry (2010-03-04)
Hao Wu, Xilei Xie, Gang Liu
ABSTRACT

Three diversity points of 4(3H)-quinazolinone are introduced at the 3-, 6-, and 7-positions with an efficient parallel solution-phase synthetic method. A one-pot synthesis was developed that gave the key intermediate in high yield. Five hit compounds exhibit preferable activities against a panel of human tumor cell lines, which pointed out preliminary structure-activity relationships.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
4-Hydroxyquinazoline, 98%