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2-methoxy-1,4-naphthoquinone isolated from Impatiens balsamina in a screening program for activity to inhibit Wnt signaling.

Journal of natural medicines (2010-10-05)
Naomi Mori, Kazufumi Toume, Midori A Arai, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi
ABSTRACT

A screening study using a luciferase assay to identify natural products which inhibit Wnt signaling was carried out. The bioassay-guided fractionation of aerial parts of a plant, Impatiens balsamina, led to the isolation of 2-methoxy-1,4-naphthoquinone (1) as an active compound. Compound 1 inhibited the TCF/β-catenin (TOP) transcriptional activity (IC(50) 2.9 µM), while it decreased the transcriptional activity of FOP (mutated TCF-binding site)-transfected cells at >5 µM.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
2-Methoxy-1,4-naphthoquinone, 98%