Influence of bromfenvinfos alone and in mixture with methoxychlor on the blood indices of laboratory mice.

Bromfenvinfos (O,O-diethyl-O-1-(2,4-dichlorphenyl)-2-bromvinyl phosphate, BrV, 12.23 mg/kg/day) alone and in combination with methoxychlor (1,1,1-trichlor-2,2-(4-methoxyphenyl) ethane, MeOCl, 24.66 mg/kg/day) were administered per os daily for 6 weeks to male and female laboratory mice in the olive-oil suspension. Total leukocyte and erythrocyte count, hemoglobin level, the percentage of leukocytes and the plasma proteins were determined. BrV and BrV + MeOCl depressed the blood hemoglobin level; BrV and BrV + MeOCl treatment reduced also the erythrocyte diameter.