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Platinum (II) complexes of benzoic- and 3-methoxybenzoic acid hydrazides. Synthesis, characterization, and cytotoxic effect.

Journal of inorganic biochemistry (1994-05-15)
N Dodoff, K Grancharov, R Gugova, N Spassovska
ABSTRACT

The complexes [Pt(bah)2X2], [Pt(NH3)(bah)Cl2].0.5H2O, [Pt(mbah)2X2], and [Pt(NH3)(mbah)Cl2] (bah = benzoic acid hydrazide, mbah = 3-methoxybenzoic acid hydrazide; X = Cl, Br, I) have been prepared and characterized by elemental analysis, electric conductivity, IR, 1H NMR, and electronic spectra. A cis-square planar structure with hydrazide ligands coordinated via the NH2-groups has been proposed for these complexes. The complexes have shown a growth-inhibitory effect against Friend leukemia cells in culture comparable to that of the antitumor drug cisplatin.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
3-Methoxybenzoic acid, ReagentPlus®, 99%
Sigma-Aldrich
m-Anisic acid, ≥98%