Identification of 2-(2'-octenyl) succinic acid in urine.

Rapid communications in mass spectrometry : RCM (1990-05-01)
G Giordano, W J McMurray, S F Previs, R D Welch, P Rinaldo
ABSTRACT

2-(2'-octenyl)succinic acid has been identified in urine samples from children investigated for a possible inherited metabolic disease. Its structural identification has been achieved by gas chromatography/mass spectrometry using both electron ionization and chemical ionization and by tandem mass spectrometry (MS/MS) using fast-atom bombardment and high-resolution electron-ionization analyses of the molecular ion in a complex biological matrix. The localization of the double bond was obtained by interpretation of a unexpected rearrangement reaction occurring after dimethyl disulfide derivatization.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
2,2-Dimethylsuccinic acid, 99%