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Solution-phase synthesis of an aminomethyl-substituted biaryl library via sequential amine N-alkylation and Suzuki cross-coupling.

Journal of combinatorial chemistry (2001-09-11)
M G Organ, E A Arvanitis, C E Dixon, D J Lavorato
ABSTRACT

Described herein is the semiautomated preparation of a 20-member aminomethyl-substituted biaryl library. The two-step solution-phase synthesis was achieved via sequential N-alkylation of various amines with either 3- or 4-bromobenzyl bromide and Suzuki cross-coupling of the resultant aryl bromides with various boronic acids.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
4-Bromobenzyl bromide, 98%

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