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Quinine blocks a calcium-activated potassium conductance in mammalian enteric neurones.

British journal of pharmacology (1984-09-01)
E Cherubini, R A North, A Surprenant
ABSTRACT

Quinine (100 microM) abolished the slow calcium-dependent afterhyperpolarization which occurs after an action potential in some neurones of the guinea-pig myenteric and submucous plexus. This occurred without any effect on the amplitude or time course of the action potential itself, or on the faster calcium-independent afterhyperpolarization. Tetraethylammonium did not reduce the slow afterhyperpolarization. Quinine also abolished the hyperpolarization which was evoked by intracellular injection of calcium ions.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Quinine hydrochloride dihydrate, tested according to Ph. Eur.