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Cytotoxic deoxybenzoins and diphenylethylenes from Arundina graminifolia.

Journal of natural products (2013-09-26)
Qiu-Fen Hu, Bin Zhou, Yan-Qing Ye, Zhi-Yong Jiang, Xiang-Zhong Huang, Yin-Ke Li, Gang Du, Guang-Yu Yang, Xue-Mei Gao
ABSTRACT

Eight new C-4-alkylated deoxybenzoins (1-8), three new diphenylethylenes (9-11), and five known diphenylethylenes were isolated from Arundina graminifolia. The structures of 1-11 were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Compounds 9-11 are the first naturally occurring diphenylethylenes possessing a hydroxyethyl unit. Compounds 1-11 were evaluated for cytotoxicity against five human tumor cell lines. Compounds 4, 5, and 9-11 showed significant cytotoxicity against five cancer cell lines, with IC50 values ranging from 1.8 to 8.7 μM.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Benzoin, 98%
Sigma-Aldrich
Benzoin, purified by sublimation, ≥99.5%

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