Dissolved organic matter (DOM) in leachate samples collected at Laogang Sanitary Landfill in Shanghai, China were fractionated using size exclusion chromatography and were characterized using estrogen receptor-alpha competitor screening assay as toxicity activity index. The estrogen activity of leachate was determined mainly by the hydrophobic acid DOM with moderate MW (3000-14,000 Da) and low MW (<630 Da) and with high aromaticity and fluorophores of possibly pyrenyl characteristics. Landfilling for up to seven years or oxic storage for one month degraded a few of these estrogens. Aerobic SBR treatments effectively degraded the hydrophobic estrogens, but rarely degraded the hydrophilic estrogens.
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