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Itraconazole treatment of nonmeningeal coccidioidomycosis in children: two case reports and review of the literature.

The Pediatric infectious disease journal (2009-11-04)
James D Homans, LaShonda Spencer
ABSTRACT

Coccidioides immitis causes a wide range of disease in humans. Fluconazole and itraconazole are effective treatments. Clinical evidence suggests that itraconazole is equivalent or superior to fluconazole in treating osteoarticular infections in rates of cure and recurrence. We report 2 cases of coccidioidomycosis involving bone in children successfully treated with itraconazole oral solution. Itraconazole oral solution is effective in treating nonmeningeal coccidioidomycosis in children, particularly skeletal disease, and infections that are refractory to fluconazole.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Itraconazole, ≥98% (TLC)
Itraconazole, European Pharmacopoeia (EP) Reference Standard
Supelco
Itraconazole solution, 2.0 mg/mL (Methanol with 1% 1M HCl), ampule of 1 mL, certified reference material, Cerilliant®
Itraconazole for system suitability, European Pharmacopoeia (EP) Reference Standard

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