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Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery.

ACS nano (2009-02-12)
Monty Liong, Jie Lu, Michael Kovochich, Tian Xia, Stefan G Ruehm, Andre E Nel, Fuyuhiko Tamanoi, Jeffrey I Zink
ABSTRACT

Drug delivery, magnetic resonance and fluorescence imaging, magnetic manipulation, and cell targeting are simultaneously possible using a multifunctional mesoporous silica nanoparticle. Superparamagnetic iron oxide nanocrystals were encapsulated inside mesostructured silica spheres that were labeled with fluorescent dye molecules and coated with hydrophilic groups to prevent aggregation. Water-insoluble anticancer drugs were delivered into human cancer cells; surface conjugation with cancer-specific targeting agents increased the uptake into cancer cells relative to that in non-cancerous fibroblasts. The highly versatile multifunctional nanoparticles could potentially be used for simultaneous imaging and therapeutic applications.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Oleylamine, technical grade, 70%