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One-pot chemoenzymatic multicomponent synthesis of thiazole derivatives.

Molecules (Basel, Switzerland) (2013-11-02)
Hui Zheng, Yi-Jia Mei, Kui Du, Xian-Ting Cao, Peng-Fei Zhang
ABSTRACT

A novel chemoenzymatic one-pot multicomponent synthesis of thiazole derivatives was developed. A series of thiazole derivatives were synthesized with high yields up to 94% under mild enzyme-catalyzed conditions. The blank and control experiments reveal that trypsin from porcine pancreas (PPT) displayed great catalytic activity to promote this reaction and showed a wide tolerance range towards different substrate amines. This trypsin-catalyzed multicomponent conversion method provides a novel strategy to synthesize thiazole derivatives and expands the application of enzymes in organic synthesis.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Trypsin from porcine pancreas, Proteomics Grade, BioReagent, Dimethylated

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