• Home
  • Search Results
  • Improved long-term memory via enhancing cGMP-PKG signaling requires cAMP-PKA signaling.

Improved long-term memory via enhancing cGMP-PKG signaling requires cAMP-PKA signaling.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (2014-05-13)
Eva Bollen, Daniela Puzzo, Kris Rutten, Lucia Privitera, Jochen De Vry, Tim Vanmierlo, Gunter Kenis, Agostino Palmeri, Rudi D'Hooge, Detlef Balschun, Harry M W Steinbusch, Arjan Blokland, Jos Prickaerts

Memory consolidation is defined by the stabilization of a memory trace after acquisition, and consists of numerous molecular cascades that mediate synaptic plasticity. Commonly, a distinction is made between an early and a late consolidation phase, in which early refers to the first hours in which labile synaptic changes occur, whereas late consolidation relates to stable and long-lasting synaptic changes induced by de novo protein synthesis. How these phases are linked at a molecular level is not yet clear. Here we studied the interaction of the cyclic nucleotide-mediated pathways during the different phases of memory consolidation in rodents. In addition, the same pathways were studied in a model of neuronal plasticity, long-term potentiation (LTP). We demonstrated that cGMP/protein kinase G (PKG) signaling mediates early memory consolidation as well as early-phase LTP, whereas cAMP/protein kinase A (PKA) signaling mediates late consolidation and late-phase-like LTP. In addition, we show for the first time that early-phase cGMP/PKG signaling requires late-phase cAMP/PKA-signaling in both LTP and long-term memory formation.

Product Number
Product Description

Rolipram, solid, ≥98% (HPLC)

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon


Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.