The role of epoxyeicosatrienoic acids in the cardiovascular system.

British journal of clinical pharmacology (2015-02-07)
L Yang, K Mäki-Petäjä, J Cheriyan, C McEniery, I B Wilkinson
ABSTRACT

There is increasing evidence suggesting that epoxyeicosatrienoic acids (EETs) play an important role in cardioprotective mechanisms. These include regulating vascular tone, modulating inflammatory responses, improving cardiomyocyte function and reducing ischaemic damage, resulting in attenuation of animal models of cardiovascular risk factors. This review discusses the current knowledge on the role of EETs in endothelium-dependent control of vascular tone in the healthy and in subjects with cardiovascular risk factors, and considers the pharmacological potential of targeting this pathway.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
11,12-Epoxy-(5Z,8Z,14Z)-eicosatrienoic acid, ~100 μg/mL in ethanol, ≥95%

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