Catalytic Asymmetric Total Synthesis of (-)-Actinophyllic Acid.

Journal of the American Chemical Society (2016-02-26)
Lingchao Cai, Kui Zhang, Ohyun Kwon
ABSTRACT

Described herein is a catalytic asymmetric total synthesis of (-)-actinophyllic acid, with the key step being a chiral phosphine-catalyzed [3 + 2] annulation between an imine and an allenoate to form a pyrroline intermediate in 99% yield and 94% ee. The synthesis also features CuI-catalyzed coupling between a ketoester and a 2-iodoindole to shape the tetrahydroazocine ring; intramolecular alkylative lactonization; SmI2-mediated intramolecular pinacol coupling between ketone and lactone subunits to assemble the complex skeleton of (-)-actinophyllic acid; and an unprecedented regioselective dehydroxylation.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Endo-Phenyl Kwon [2.2.1] Bicyclic Phosphine, 95% (HPLC)
Sigma-Aldrich
Endo-4-Methoxyphenyl Kwon [2.2.1] Bicyclic Phosphine

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