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Synthesis and dopaminergic activity of 2-substituted octahydrobenzo[f]quinolines.

Journal of medicinal chemistry (1989-05-01)
J C Craig, S M Torkelson, P R Findell, R I Weiner
ABSTRACT

A series of 2-substituted octahydrobenzo[f]quinolines has been synthesized and assayed for dopamine agonist activity. Only the compounds corresponding to the beta-rotameric conformation of dopamine showed biphasic activity in competition binding studies with the radioligand [3H]spiroperidol. These findings suggest that the congeners possessing the beta-rotamer conformation show receptor-binding characteristics that resemble those of the ergolines more closely than do those of the corresponding alpha-rotamer congeners.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
7-Methoxy-2-tetralone, 97%
Sigma-Aldrich
6,7-Dimethoxy-1-tetralone, 97%