• Home
  • Search Results
  • 1-alkyl-4-acylpiperazines as a new class of imidazole-free histamine H(3) receptor antagonists.

1-alkyl-4-acylpiperazines as a new class of imidazole-free histamine H(3) receptor antagonists.

Journal of medicinal chemistry (2004-05-14)
Florencio Zaragoza, Henrik Stephensen, Sanne M Knudsen, Lone Pridal, Birgitte S Wulff, Karin Rimvall
ABSTRACT

With the aim of identifying structurally novel, centrally acting histamine H(3) antagonists, arrays of monoacyldiamines were screened. This led to the discovery of a series of 1-alkyl-4-acylpiperazines which were potent antagonists at the human histamine H(3) receptor. The most potent amides had antagonist potencies in the subnanomolar range.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
1-Boc-piperazine, 97%