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Enantioselective hydrogenation of tetrasubstituted olefins of cyclic beta-(acylamino)acrylates.

Journal of the American Chemical Society (2003-08-09)
Wenjun Tang, Shulin Wu, Xumu Zhang
ABSTRACT

Hydrogenation of a series of cyclic beta-(acylamino)acrylates with tetrasubstituted olefins has been accomplished successfully with the use of Ru catalysts with chiral biaryl ligands such as C3-TunaPhos, and up to over 99% ee's have been achieved. This methodology provides an efficient catalytic method for the synthesis of both cis and trans chiral cyclic beta-amino acid derivatives.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
(R)-C3-TunePhos-ruthenium complex

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