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MiR-876-5p suppresses epithelial-mesenchymal transition of lung cancer by directly down-regulating bone morphogenetic protein 4.

Journal of biosciences (2017-12-13)
Liang Bao, Lei Lv, Jinping Feng, Yuyu Chen, Xinhua Wang, Shuguang Han, Hongqing Zhao
ABSTRACT

Lung cancer is the leading cause of cancer-related death throughout the world. We aimed to investigate the role of a novel microRNA-876-5p and its potential molecular target bone morphogenetic protein 4 (BMP-4), in the epithelial-mesenchymal transition (EMT) of lung cancer. Expressions of microRNA-876-5p and its potential target BMP-4 were analysed in lung cancer cells and patient tissues. Luciferase activity assay was conducted to verify direct targeting of microRNA- 876-5p to the 3'-UTR of BMP-4 mRNA. Migration, invasion capacities of lung cancer cells expressing microRNA-876-5p were analysed, and characteristics of lung cancer EMT protein markers were also evaluated. A xenograft tumour mouse model was established to address the roles of microRNA-876-5p and BMP-4 in lung cancer EMT

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
MISSION® Lenti microRNA, Human, Negative Control 1
Sigma-Aldrich
MISSION® Lenti microRNA, Human, hsa-miR-876-5p

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