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A new class of easily activated palladium precatalysts for facile C-N cross-coupling reactions and the low temperature oxidative addition of aryl chlorides.

Journal of the American Chemical Society (2008-05-02)
Mark R Biscoe, Brett P Fors, Stephen L Buchwald
ABSTRACT

A new class of one-component Pd precatalysts bearing biarylphosphine ligands is described. These precatalysts are air- and thermally stable, are easily activated under normal reaction conditions at or below room temperature, and ensure the formation of the highly active monoligated Pd(0) complex necessary for oxidative addition. The use of these precatalysts as a convenient source of LPd(0) in C-N cross-coupling reactions is explored. The reactivity that is demonstrated in this study is unprecedented in palladium chemistry.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
RuPhos Pd G1 Methyl -Butyl Ether Adduct, 95%
Sigma-Aldrich
SPhos Pd G1, Methyl t-Butyl Ether Adduct
Sigma-Aldrich
3-Chlorophenethyl alcohol, 98%