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Selective monoarylation of acetate esters and aryl methyl ketones using aryl chlorides.

Organic letters (2009-03-20)
Mark R Biscoe, Stephen L Buchwald
ABSTRACT

Simple, efficient procedures for the monoarylation of acetate esters and aryl methyl ketones using aryl chlorides are presented. Previously, no general method was available to ensure the highly selective monoarylation of these classes of substrates using aryl chlorides. Using palladium precatalysts recently reported by our group, these reactions are easily accomplished under mild conditions that tolerate a wide array of heterocyclic substrates.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
tBuXPhos Pd G1