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Merck

HLA-B

major histocompatibility complex, class I, B

別名:
AS, HLAB, SPDA1
Species:
Human HLA-B (3106)
UniProtKB ID:
P30464, B0V0B8, P30465, P30513, Q29633, Q29636, Q29829, Q29953
遺伝子ID:
  • Human(3106) Summary: HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]

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Antibodies

製品番号
詳細
交差性
アプリケーション
MAB1285FX
Anti-HLA-B27,Cln HLA-ABC-m3 FITC (mouse monoclonal), clone HLA-ABC-m3, Chemicon®, from mouse,
交差性
human
アプリケーション
flow cytometry
MAB1288
Anti-HLA-B7 Antibody, clone BB7.1, PE Conjugate, clone BB7.1, Chemicon®, from mouse,
交差性
human
アプリケーション
flow cytometry
MAB1285
Anti-HLA-B27,Cln HLA-ABC-m3 (mouse monoclonal), clone HLA-ABC-m3, Chemicon®, from mouse,
交差性
human
アプリケーション
flow cytometry
immunocytochemistry
ZRB2779
Anti-HLA-B Antibody, clone 1L21 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
交差性
human
アプリケーション
affinity binding assay
flow cytometry
immunofluorescence
immunohistochemistry
western blot
MAB1285F
Anti-HLA-B27,Cln HLA-ABC-m3 FITC (mouse monoclonal), clone HLA-ABC-m3, Chemicon®, from mouse,
交差性
human
アプリケーション
flow cytometry
immunofluorescence