1.07098

8-Hydroxyquinoline

GR for analysis Reag. Ph Eur

• Synonym(e): Oxin, 8-Chinolinol
• Empirische Formel (Hill-System): C₉H₇NO
• CAS-Nummer: 148-24-3
• Molekulargewicht: 145.16
• MDL-Nummer: MFCD00006807
• UNSPSC-Code: 12352104
• EG-Index-Nummer: 205-711-1
• NACRES: NA.21

Eigenschaften

• Agentur: reag. Ph. Eur.
• Qualitätsniveau: 200
• Form: solid
• Wirksamkeit: 1200 mg/kg LD₅₀, oral (Rat)
• bp: 267 °C/1013 hPa
• mp (Schmelzpunkt): 72.5-74.0 °C
• Dichte: 1.034 g/cm³ at 20 °C
• Lagertemp.: 15-25°C
• SMILES String: n1c2c(ccc1)cccc2O
• InChI: 1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H
• InChIKey: MCJGNVYPOGVAJF-UHFFFAOYSA-N

Beschreibung

Anwendung

• Pseudo-water-soluble Fe(2)O(3) as Nanozyme catalyzed chemiluminescent reaction for detection of brilliant blue in gelatin and beverages.: This innovative study utilizes 8-Hydroxyquinoline for enhancing chemiluminescent reactions in the detection of food colorants, presenting a new avenue in food safety and quality assurance techniques (Jabbar HS, 2024).


• Enhanced selectivity towards melanoma cells with zinc(II)-Schiff bases containing imidazole derivatives.: Incorporating 8-Hydroxyquinoline in the development of zinc(II)-Schiff base complexes, this research demonstrates potential therapeutic applications in targeting melanoma cells, highlighting its role in medicinal chemistry (Côrte-Real et al., 2024).


• Synthesis, crystal structure and anti-cancer activity of the complex chlorido-(η(2)-ethyl-ene)(quinolin-8-olato-κ(2)N,O)platinum(II) by experimental and theoretical methods.: This paper details the synthesis and anti-cancer properties of a novel platinum(II) complex using 8-Hydroxyquinoline, offering insights into its structural characteristics and therapeutic potential (Chi NTT et al., 2024).


• Anticancer activity of 8-hydroxyquinoline-triphenylphosphine rhodium(III) complexes targeting mitophagy pathways.: Exploring the use of 8-Hydroxyquinoline in rhodium(III) complexes, this study provides a new perspective on targeting cancer cell metabolism, specifically through mitophagy pathways (Huang XQ et al., 2024).


• Mitochondria-localizing triphenylphosphine-8-hydroxyquinoline Ru complexes induce ferroptosis and their antitumor evaluation.: This research examines the effectiveness of 8-Hydroxyquinoline complexes in inducing ferroptosis in cancer cells, a novel approach in cancer therapy focusing on oxidative cell death mechanisms (Meng T et al., 2024).

Hinweis zur Analyse

Gehalt (Perchlorsäuretitration): ≥ 99
Identität (IR-Spektrum): entspricht
In Ethanol unlösliche Anteile: ≤ 0.05 %
Schmelzpunkt: 73 - 75 °C
Chlorid (Cl): ≤ 0.001 %
Sulfat (SO₄): ≤ 0.01 %
Sulfatasche: ≤ 0.05 %
Eignung als Reagenz (für den Mg-Nachweis): entspricht

Sicherheitshinweise

• Piktogramme: GHS05,GHS06,GHS08,GHS09
• Signalwort: Danger
• H-Sätze: H301 - H317 - H318 - H360D - H410
• P-Sätze: P202 - P273 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Repr. 1B - Skin Sens. 1
• Lagerklassenschlüssel: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable