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217505

CBP-CREB Interaction Inhibitor

The CBP-CREB Interaction Inhibitor, also referenced under CAS 92-78-4, controls the biological activity of CBP-CREB.

Synonym(e):

CBP-CREB Interaction Inhibitor, Luciferase Inhibitor III, N-(4-Chlorophenyl)-3-hydroxy-2-naphthamide, KIX-KID Interaction Inhibitor

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Über diesen Artikel

Empirische Formel (Hill-System):
C17H12ClNO2
CAS-Nummer:
92-78-4
Molekulargewicht:
297.74
MDL-Nummer:
MFCD00021639
UNSPSC-Code:
12352200
NACRES:
NA.77

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Qualitätsniveau

100

Assay

≥97% (HPLC)

Form

solid

Hersteller/Markenname

Calbiochem®

Lagerbedingungen

OK to freeze
protect from light

Farbe

beige

Löslichkeit

DMSO: 100 mg/mL

Versandbedingung

ambient

Lagertemp.

2-8°C

SMILES String

Clc1ccc(cc1)NC(=O)c2cc3c(cc2O)cccc3

InChI

1S/C17H12ClNO2/c18-13-5-7-14(8-6-13)19-17(21)15-9-11-3-1-2-4-12(11)10-16(15)20/h1-10,20H,(H,19,21)

InChIKey

OHAXNCGNVGGWSO-UHFFFAOYSA-N

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Dieser Artikel
324517407625171260
CBP-CREB Interaction Inhibitor The CBP-CREB Interaction Inhibitor, also referenced under CAS 92-78-4, controls the biological activity of CBP-CREB.

Sigma-Aldrich

217505

CBP-CREB Interaction Inhibitor

eIF4E/eIF4G-Interaktions-Inhibitor, 4EGI-1 The eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, also referenced under CAS 315706-13-9, controls the biological activity of eIF4E/eIF4G interaction. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

324517

eIF4E/eIF4G-Interaktions-Inhibitor, 4EGI-1

STAT3 Inhibitor XVI The STAT3 Inhibitor XVI controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

407625

STAT3 Inhibitor XVI

AMPK-Inhibitor, Verbindung C AMPK Inhibitor, Compound C, CAS 866405-64-3, is a cell-permeable compound that inhibits KDR/VEGFR2, ALK2/BMPR-I, and AMPK kinase activities (IC50 = 25.1, 148, and 234.6 nM, respectively).

Sigma-Aldrich

171260

AMPK-Inhibitor, Verbindung C

assay

≥97% (HPLC)

assay

≥98% (sum of two isomers, HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

form

solid

form

solid

form

solid

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

Allgemeine Beschreibung

A cell-permeable naphthamide compound that effectively blocks the interaction between the KIX domain of CBP and the KID domain of CREB in HEK293T-based and cell-free Renilla luciferase (RLuc) complementation assays (IC50 = 2.26 and 2.9 µM, respectively) by directly binding to CBP′s KIX domain (Kd ~8.6 µM using a recombinant KIX). Shown to inhibit CRE- (cAMP response element) dependent transcription activity induced by forskolin (Cat. No. 344270) in a HEK293T-based RLuc reporter assay (IC50<2.5 µM), while exhibiting little effect against the KID-independent CREB-VP16 transcription activity. Also reported to inhibit the enzymatic activity of Firefly luciferase (IC50 ~1 µM), but not that of RLuc.

Verpackung

Packaged under inert gas

Angaben zur Herstellung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Sonstige Hinweise

Li, B.X. and Xiao, X., 2009. ChemBioChem10, 2721.
Best, J.L., et al. 2004. Proc. Natl. Acad. Sci. USA101, 17622.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Toxicity: Standard Handling (A)

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H317,H319

Gefahreneinstufungen

Eye Irrit. 2 - Skin Sens. 1B

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 1

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