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Merck

B2635

1,4-Butandiol-dimethansulfonat

analytical standard, for drug analysis

Synonym(e):

Busulfan

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10 G

€ 37,40

25 G

€ 76,10

€ 37,40


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Über diesen Artikel

Lineare Formel:
CH3SO2O(CH2)4OSO2CH3
CAS-Nummer:
Molekulargewicht:
246.30
Beilstein:
1791786
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
41116107
PubChem Substanz-ID:
NACRES:
NA.24

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Qualitätsniveau

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

mp (Schmelzpunkt)

114-117 °C (lit.)

Anwendung(en)

forensics and toxicology
veterinary

Format

neat

SMILES String

CS(=O)(=O)OCCCCOS(C)(=O)=O

InChI

1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3

InChIKey

COVZYZSDYWQREU-UHFFFAOYSA-N

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Dieser Artikel
B1385B3022B1170000
Busulfan European Pharmacopoeia (EP) Reference Standard

B1170000

Busulfan

application(s)

forensics and toxicology
veterinary

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

application(s)

forensics and toxicology
veterinary

application(s)

pharmaceutical (small molecule)

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

grade

analytical standard, for drug analysis

grade

analytical standard, for drug analysis

grade

analytical standard, for drug analysis

grade

pharmaceutical primary standard

format

neat

format

neat

format

neat

format

neat

mp

114-117 °C (lit.)

mp

-

mp

-

mp

114-117 °C (lit.)

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

-

Allgemeine Beschreibung

Busulfan is a bifunctional alkylating agent[1], which may find application in the treatment of chronic granulocytic leukemia.[1]

Anwendung

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Piktogramme

Skull and crossbonesHealth hazard

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Oral - Carc. 1A - Muta. 1B - Repr. 1B

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Blood and Marrow Stem Cell Transplantation: Principles, Practice, and Nursing Insights (1997)
Arnon Nagler et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(28), 3549-3556 (2013-08-28)
Cyclophosphamide (Cy) combined with total-body irradiation (TBI) or with busulfan (Bu) are currently the most common myeloablative regimens used in allogeneic stem-cell transplantation (alloSCT) in adults with acute myelogenous leukemia (AML). Intravenous (IV) Bu has more predictable bioavailability and a
Moustapha Hassan et al.
Pharmacogenomics, 14(1), 75-87 (2012-12-21)
Hematopoietic stem cell transplantation (HSCT) is a curative treatment for several malignant and nonmalignant disorders. Busulfan (Bu) and cyclophosphamide (Cy) are the most commonly used alkylators in high-dose pretransplant conditioning for HSCT; a treatment that is correlated with drug-related toxicity
Donna Reece et al.
The oncologist, 18(5), 611-618 (2013-05-01)
Multiple myeloma is a malignancy of B cells characterized by accumulation of abnormal plasma cells in the bone marrow. In the past 20 years, the use of high-dose therapies and novel agents has resulted in significant and meaningful improvements in
M Hassan et al.
Leukemia & lymphoma, 22(5-6), 395-407 (1996-08-01)
Busulfan as a high-dose therapy is an important component of many of the myeloablative regimens for both allogeneic and autologous bone marrow transplantation (BMT) in adults and children. During the last decade, several studies have shown a wide inter- and

Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. SDSに保管温度や溶解条件等が見当たらないので教えていただけますでしょうか。また、現在HPLCの標準物質として使用しており、MeOHに溶解後、乾固凍結、使用時に再溶解しています。溶解後の保存についても最適な方法(乾固の有無・温度・期間)を教えてください。

    1 answer
    1. The neat product is to be stored at room temperature. Busulfan is soluble in organic solvents such as DMSO and dimethyl formamide. The solubility of busulfan in these solvents is approximately 16.7 mg/ml. No solution stability studies are performed for this compound but the literature recommends using the prepared solution within 24 hours.

      Helpful?

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