Acylase I aus Schweineniere

Name: Acylase I aus Schweineniere
Brand: SIGMA

Grade II, salt-free, lyophilized powder, 300-1,500 units/mg protein

Synonym(e):

Aminoacylase, N-Acylaminosäure-Amidohydrolase

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CAS-Nummer:

9012-37-7

UNSPSC Code:

12352204

NACRES:

NA.54

EC Number:

232-732-3

MDL number:

MFCD00081285

EG-Nummer:

3.5.1.14 (BRENDA, IUBMB)

Specific activity:

300-1,500 units/mg protein

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Eigenschaften

type

Grade II

Quality Segment

200

form

salt-free, lyophilized powder

specific activity

300-1,500 units/mg protein

UniProt accession no.

P37111

storage temp.

−20°C

Gene Information

pig ... ACY1(396930)

Beschreibung

Application

Acylase I from porcine kidney has been used to study the acylase I-catalyzed deacetylation of various S-alkyl-N-acetyl-L-cysteines and their carbon and oxygen analogues . Acylase I may be useful to catalyze N-acetyl amino acids to enantiomerically pure L-amino acids .

Biochem/physiol Actions

Acylase I is a zinc metalloprotein that catalyzes the kinetic resolution of unnatural and rarely occurring α-amino acids. Its enantioselectivity for the hydrolysis of N-acyl L-α-amino acids is nearly absolute, yet it accepts substrates having a wide range of structure and functionality. Acylase I catalyzes the deacetylation of N-acetyl-L-cysteine and S-alkyl-N-acetyl-L-cysteines. n-Butylmalonic acid is an inhibitor of acylase I. S-alkyl-N-acetyl-L-cysteines with short (C0-C3) and unbranched S-alkyl substituents have been found to be good acylase I substrates.