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G7504

Guanosin 3′,5′-zyklisches Monophosphat

≥98% (HPLC), powder, intracellular mediator

Synonym(e):

Cyclisches GMP, cGMP

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€ 56,10

25 MG

€ 240,00

100 MG

€ 721,00

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Über diesen Artikel

Empirische Formel (Hill-System):
C10H12N5O7P
CAS-Nummer:
7665-99-8
Molekulargewicht:
345.21
NACRES:
NA.77
PubChem Substance ID:
24895309
UNSPSC Code:
41106305
EC Number:
231-641-6
MDL number:
MFCD00070129

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Produktname

Guanosin 3′,5′-zyklisches Monophosphat, ≥98% (HPLC), powder

InChI key

ZOOGRGPOEVQQDX-UHFFFAOYSA-N

InChI

1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)

SMILES string

NC1=NC(=O)c2ncn(C3OC4COP(O)(=O)OC4C3O)c2N1

assay

≥98% (HPLC)

form

powder

color

white

solubility

0.2 M NaHCO3: 50 mg/mL

storage temp.

−20°C

Quality Level

200

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Dieser Artikel
G6129C5438370660
Guanosin 3′,5′-zyklisches Monophosphat ≥98% (HPLC), powder

Sigma-Aldrich

G7504

Guanosin 3′,5′-zyklisches Monophosphat

Guanosin-3′,5′-cyclophosphat Natriumsalz ≥99% (HPLC), powder

Sigma-Aldrich

G6129

Guanosin-3′,5′-cyclophosphat Natriumsalz

8-(4-Chlorophenylthio)-guanosine 3′,5′-cyclic monophosphate sodium salt ≥95% (HPLC), powder

Sigma-Aldrich

C5438

8-(4-Chlorophenylthio)-guanosine 3′,5′-cyclic monophosphate sodium salt

Guanosine 3′,5′-cyclic Monophosphate, N²,2′-O-Dibutyryl-, Sodium Salt Cell-permeable cGMP analog that preferentially activates protein kinase G.

Sigma-Aldrich

370660

Guanosine 3′,5′-cyclic Monophosphate, N²,2′-O-Dibutyryl-, Sodium Salt

assay

≥98% (HPLC)

assay

≥99% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

form

powder

form

powder

form

powder

form

solid

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

0.2 M NaHCO3: 50 mg/mL

solubility

H2O: 50 mg/mL

solubility

H2O: 25 mg/mL

solubility

ethanol: soluble, water: soluble

color

white

color

white

color

white

color

white

Biochem/physiol Actions

A major intracellular mediator of extracellular signals such as nitric oxide and natriuretic peptides.
An important second messenger, cGMP is a major intracellular mediator of extracellular signals such as nitric oxide and natriuretic peptides. Cyclic GMP interacts with three types of intracellular receptor proteins: cGMP-dependent protein kinases, cGMP-regulated channels, and cGMP-regulated cyclic nucleotide phosphodiesterases. A primary action of elevated cGMP levels in vivo is the stimulation of cGMP-dependent protein kinase (PKG).

Features and Benefits

This compound is a featured product for ADME Tox and Cyclic Nucleotide research. Discover more featured ADME Tox and Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000514231
0000514229
0000514227
0000514227
0000514229

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Molecular therapy. Methods & clinical development, 14, 134-147 (2019-07-25)
Ex vivo retroviral gene transfer into CD34+ hematopoietic stem and progenitor cells (HSPCs) has demonstrated remarkable clinical success in gene therapy for monogenic hematopoietic disorders. However, little attention has been paid to enhancement of culture and transduction conditions to achieve reliable
Ko-Hsin Chin et al.
Acta crystallographica. Section D, Biological crystallography, 69(Pt 3), 352-366 (2013-03-23)
The mammalian ER protein STING (stimulator of interferon genes; also known as MITA, ERIS, MPYS or TMEM173) is an adaptor protein that links the detection of cytosolic dsDNA to the activation of TANK-binding kinase 1 (TBK1) and its downstream transcription
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Aging and disease, 10(4), 684-698 (2019-08-24)
Advanced chronic liver disease (aCLD) represents a major public health concern. aCLD is more prevalent and severe in the elderly, carrying a higher risk of decompensation. We aimed at understanding how aging may impact on the pathophysiology of aCLD in
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