S1451

Anti-Sox2 antibody, Mouse monoclonal

clone SOX2-6, purified from hybridoma cell culture

• Synonym(e): Anti-ANOP3, Anti-MCOPS3, Anti-SRY (sex determining region Y)-box 2, Anti-SRY-related HMG-box gene 2, Anti-Sex-determining region Y-box 2
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Konjugat: unconjugated
• Antikörperform: purified from hybridoma cell culture
• Antikörper-Produkttyp: primary antibodies
• Klon: SOX2-6, monoclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen ~35 kDa
• Speziesreaktivität: human, mouse
• Konzentration: ~1.0 mg/mL
• Methode(n): western blot: 0.5-1.0 μg/mL using whole extract of human NT2 cells
• Isotyp: IgG1
• UniProt-Hinterlegungsnummer: P48431
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... SOX2(6657) ; mouse ... Sox2(20674) ; rat ... Sox2(499593)

Beschreibung

Allgemeine Beschreibung

Monoclonal Anti-SOX2 (mouse IgG1 isotype) is derived from the hybridoma SOX2-6 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice.

SOX2 (sex-determining region Y-box 2) is a transcription factor that is made of 317 amino acid. It has a HMG (high mobility group box) domain and is a critical transcription regulator of normal stem cell. It is located on human chromosome 3q26.3.

Anwendung

Anti-Sox2 antibody has been used in western blotting and immunohistochemistry.

Biochem./physiol. Wirkung

Mutations in the SOX2 gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation.

SOX2 (sex-determining region Y-box 2) down-regulation reduces the stem cell count, that affects the breast cancer cells in initiating tumor progression. It participates in chemoresistance and regular lung cancer therapies. In mouse, SOX2 plays an important role in branching morphogenesis and regulating lung epithelial cell differentiation.

Physikalische Form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable